Article
Possible involvement of lysophosphatidic acid receptor-5 gene in the acquisition of growth advantage of rat tumor cells.
Molecular carcinogenesis - 1 Aug 2011
Okabe Kyoko, Hayashi Mai, Yamawaki Yasuna, Teranishi Miki, Honoki Kanya, Mori Toshio, Fukushima Nobuyuki, Tsujiuchi Toshifumi
Abstract excerpt
Aberrant expressions of lysophosphatidic acid (LPA) receptor genes have been reported in tumor cells. Here, we measured the expression levels of the Lpa5 gene and its DNA methylation status in rat tumor cells, and investigated cell growth effects of LPA in Lpa5 expressed cells. Real-time reverse transcription (RT)-polymerase chain reaction (PCR) analysis revealed that increased expressions of the Lpa5 gene were...
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