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Article

Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion.

Oncogene - 16 Feb 2012

Wang Y, Lazo J S

Abstract excerpt

The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeutic targets. Although several studies have documented that altered expression of PRL-1 or PRL-3 can influence cell proliferation, migration and invasion, there is a dearth of knowledge about the biological functions of PRL-2. Thus, in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21765462
DOI: 10.1038/onc.2011.281
PMCID: PMC4553949

Genes

PRL

Variants

Provenance

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Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion.PMID 21765462Read ↗

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Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein.Semantic proximity Read ↗

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