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Article

Functional characterization of lysophosphatidic acid receptor 1 mutants identified in rat cancer tissues.

Biochemical and biophysical research communications - 6 May 2017

Ishii Shoichi, Tsujiuchi Toshifumi, Fukushima Nobuyuki

Abstract excerpt

Lysophosphatidic acid (LPA), an extracellular lipid mediator, exerts various cellular effects through activation of LPA receptors, LPA1-LPA6, in many types of cells including cancer cells. We recently found several missense mutations of Lpar1 in rat cancer tissues. One of these mutations is located at the extracellular tip of the seventh transmembrane domain of LPA1, and another three mutations are found within...

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Source

Identifiers

PMID: 28342860
DOI: 10.1016/j.bbrc.2017.03.118

Genes

LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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