Article
Differential function of lysophosphatidic acid receptors in cell proliferation and migration of neuroblastoma cells.
Cancer letters - 1 Mar 2012
Hayashi Mai, Okabe Kyoko, Kato Kohei, Okumura Mai, Fukui Rie, Fukushima Nobuyuki, Tsujiuchi Toshifumi
Abstract excerpt
Lysophosphatidic acid (LPA) is a bioactive lipid mediator that induces diverse cellular biological effects and interacts with G protein-coupled transmembrane LPA receptors. In the present study, to assess biological roles of LPA receptors in the pathogenesis of tumor cells, each LPA receptor (Lpar1, Lpar2 or Lpar3)-expressing rat neuroblastoma B103 cells (lpa1-1, lpa2-2 or lpa3-3-2 cells, respectively) were used....
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