Article
Mutations of lysophosphatidic acid receptor genes in human osteosarcoma cells.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2010
Okabe Kyoko, Hayashi Mai, Fujii Minako, Honoki Kanya, Mori Toshio, Fukushima Nobuyuki, Tsujiuchi Toshifumi
Abstract excerpt
OBJECTIVE: Lysophosphatidic acid (LPA), which is a bioactive phospholipid, interacts with specific G protein-coupled transmembrane receptors. Recently, alterations in LPA receptor genes have been reported in some tumor cells. In this study, to assess an involvement of LPA receptor genes in the development of human cancer cells, we looked for the presence of mutations in LPA receptor 1-6 (LPA1-6) genes in MG63...
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