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The role of oxysterol binding protein‐related protein 5 in pancreatic cancer

16 Dec 2009

Abstract excerpt

The expression of oxysterol binding protein-related protein (ORP) 5 is related to invasion and a poor prognosis in pancreatic cancer patients. ORP5 induced the expression of sterol response element binding protein (SREBP) 2 and activated the downstream gene of sterol response element. ChIP using SREBP2 antibody revealed that histone deacetylase 5 (HDAC5) was one of the downstream genes of SREBP2. The effect of...

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PMID: 20128820
DOI: 10.1111/j.1349-7006.2009.01475.x

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