Article
Regulation of O6-methylguanine-DNA methyltransferase expression in the Burkitt's lymphoma cell line Raji.
Mutation research - 1 Jan 2000
Karran P, Stephenson C, Cairns-Smith S, Macpherson P
Abstract excerpt
We have investigated the expression of the DNA-repair enzyme O6-methylguanine-DNA methyltransferase in the Burkitt's lymphoma cell line Raji. An existing mutant Raji cell line which lacks thymidine kinase activity had previously been shown to be Mex- and to no longer express O6-methylguanine-DNA...
Topics
- Blotting, Southern
- Burkitt Lymphoma
- DNA Repair
- Galactokinase
- Gene Expression Regulation, Enzymologic
- Humans
- Methyltransferases
- O(6)-Methylguanine-DNA Methyltransferase
- Phenotype
- RNA, Messenger
- Thymidine Kinase
- Transcription, Genetic
- Tumor Cells, Cultured