Epigenetic silencing of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in Mex- human cells.

Article

Epigenetic silencing of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in Mex- human cells.

Cancer research - 1 Oct 1992

Cairns-Smith S, Karran P

Abstract excerpt

Regulation of the expression of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) has been investigated in a number of human lymphoblastoid cell lines. In a number of Mex- cell lines that do not express methyltransferase activity, CpG sequences in the mgmt gene were hypomethylat...

Topics

Cytosine
DNA
DNA Repair
Gene Expression
Gene Expression Regulation, Enzymologic
Guanine
Humans
Lymphocytes
Methylation
Methyltransferases
O(6)-Methylguanine-DNA Methyltransferase
Phenotype

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