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Article

Epigenetic silencing of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in Mex- human cells.

Cancer research - 1 Oct 1992

Cairns-Smith S, Karran P

Abstract excerpt

Regulation of the expression of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) has been investigated in a number of human lymphoblastoid cell lines. In a number of Mex- cell lines that do not express methyltransferase activity, CpG sequences in the mgmt gene were hypomethylated with respect to methyltransferase-expressing Mex+ lines. In the cell line GM1953(S), in which the mgmt gene is...

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Source

Identifiers

PMID: 1394130

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epigenetic silencing of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in Mex- human cells.PMID 1394130Read ↗

Coregulation of the human O6-methylguanine-DNA methyltransferase with two unrelated genes that are closely linked.Semantic proximity Read ↗

Genomic differences between O6-methylguanine-DNA methyltransferase proficient (Mex+) and deficient (Mex-) cell lines: possible role of genetic and epigenetic changes in conversion of Mex+ into Mex-.Semantic proximity Read ↗

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.Semantic proximity Read ↗

Evidence for spontaneous conversion of Mex- to Mex+ in human lymphoblastoid cells.Semantic proximity Read ↗

Direct Correlation Between Methylation Status and Expression of the Human O-6-MethyIguanine DNA Methyltransferase GeneSemantic proximity Read ↗

Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cellsSemantic proximity Read ↗

Methylation of Discrete Regions of the O 6 -Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the GeneSemantic proximity Read ↗

Mouse methyltransferase for repair of O6-methylguanine and O4-methylthymine in DNA.Semantic proximity Read ↗

Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.Semantic proximity Read ↗

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Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.Semantic proximity Read ↗

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