Article
Complementation of mismatch repair gene defects by chromosome transfer.
Mutation research - 18 Jun 1998
Tindall K R, Glaab W E, Umar A, Risinger J I, Koi M, Barrett J C, Kunkel T A
Abstract excerpt
The study of the multiple functions of mismatch repair genes in humans is being facilitated by the use of human tumor cell lines carrying defined MMR gene mutations. Such cell lines have elevated spontaneous mutation rates and may accumulate mutations in other genes, some of which could be causal...
Topics
- Cell Fusion
- Chromosomes, Human
- DNA Repair
- Genetic Complementation Test
- Humans
- Hybrid Cells
- Mutation
- Nucleic Acid Heteroduplexes