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Article

Evidence for a functional genetic polymorphism of the Rho-GTPase Rac1. Implication in azathioprine response?

Pharmacogenetics and genomics - 1 Jun 2011

Bourgine Joanna, Garat Anne, Allorge Delphine, Crunelle-Thibaut Aurélie, Lo-Guidice Jean-Marc, Colombel Jean-Frédéric, Broly Franck, Billaut-Laden Ingrid

Abstract excerpt

BACKGROUND: Adverse effects of thiopurine drugs occur in 15-28% of patients and the majority is not explained by thiopurine-S-methyltransferase deficiency. Furthermore, approximately 9% of patients with inflammatory bowel disease are resistant to azathioprine therapy. Recently, the small guanosine triphosphatase, Rac1, was identified as an important molecular target of 6-thioguanine triphosphate, one of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammatory Bowel Diseases

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Share to Mutagenesis, Site-Directed

Share to Polymorphism, Single-Stranded Conformational

Share to Promoter Regions, Genetic

Share to rac1 GTP-Binding Protein

Source

Identifiers

PMID: 21372752
DOI: 10.1097/FPC.0b013e3283449200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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