Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High prevalence of polymorphism and low activity of thiopurine methyltransferase in patients with inflammatory bowel disease.

European journal of internal medicine - 1 Apr 2012

Larussa Tiziana, Suraci Evelina, Lentini Margherita, Nazionale Immacolata, Gallo Luigia, Abenavoli Ludovico, Imeneo Maria, Costanzo Francesco Saverio, Cuda Giovanni, Luzza Francesco

Abstract excerpt

BACKGROUND: Gene polymorphism of thiopurine methyltransferase (TPMT) correlates with decreased enzyme activity which determines a significant risk of adverse effect reactions (ADR) in patients treated with thiopurines. The aim of this study was to investigate TPMT genotype and phenotype status in patients with inflammatory bowel diseases (IBD). METHODS: Fifty-one consecutive out-patients with IBD were genotyped...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colitis, Ulcerative
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Hypersensitivity

Share to Heterozygote

Share to Homozygote

Share to Methyltransferases

Share to Prevalence

Share to Purine-Pyrimidine Metabolism, Inborn Errors

Source

Identifiers

PMID: 22385887
DOI: 10.1016/j.ejim.2011.12.002

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High prevalence of polymorphism and low activity of thiopurine methyltransferase in patients with inflammatory bowel disease.PMID 22385887Read ↗

Prospective study of the effects of concomitant medications on thiopurine metabolism in inflammatory bowel disease.Semantic proximity Read ↗

AN EPIDEMIOLOGICAL STUDY OF THIOPURINE-METHYLTRANSFERASE VARIANTS IN A CROATIAN INFLAMMATORY BOWEL DISEASE PATIENT COHORT.Semantic proximity Read ↗

Thiopurine-methyltransferase variants in inflammatory bowel disease: prevalence and toxicity in Brazilian patients.Semantic proximity Read ↗

Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease PatientsSemantic proximity Read ↗

Pharmacogenetics of Thiopurines in Inflammatory Bowel DiseaseSemantic proximity Read ↗

Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine.Semantic proximity Read ↗

Frequency of thiopurine methyltransferase mutation in patients of Mediterranean area with inflammatory bowel disease and autoimmune disorders.Semantic proximity Read ↗

Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases.Semantic proximity Read ↗

Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT.Semantic proximity Read ↗

Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease.Semantic proximity Read ↗

Clinical pharmacogenomics of thiopurine S-methyltransferase.Semantic proximity Read ↗

Nomenclature for alleles of the thiopurine methyltransferase gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.