Article
Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy.
Molecular diagnosis & therapy - 1 Dec 2016
Seinen Margien L, van Nieuw Amerongen Geerten P, de Boer Nanne K H, van Bodegraven Adriaan A
Abstract excerpt
The incidence and prevalence of inflammatory bowel disease (IBD) are increasing. Although the etiology of IBD is unknown, it is thought that genetically susceptible individuals display an inappropriate inflammatory response to commensal microbes, resulting in intestinal tissue damage. Key proteins involved in regulating the immune response, and thus in inflammation, are the small triphosphate-binding protein Rac...
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