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Article

Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease.

Inflammatory bowel diseases - 1 Jan 2007

Stocco Gabriele, Martelossi Stefano, Barabino Arrigo, Decorti Giuliana, Bartoli Fiora, Montico Marcella, Gotti Annalisa, Ventura Alessandro

Abstract excerpt

BACKGROUND: Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur in 15%-38% of patients and the majority are not explained by thiopurine-S-methyltransferase (TPMT) deficiency. Azathioprine is known to induce glutathione depletion and consumption of glutathione is greater in cells with high glutathione-S-transferase (GST) activity compared with those with low activity; moreover, some...

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Source

Identifiers

PMID: 17206640
DOI: 10.1002/ibd.20004

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease.PMID 17206640Read ↗

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Pharmacogenetics of azathioprine in inflammatory bowel disease: A role for glutathione-S-transferase?Semantic proximity Read ↗

The impact of thiopurine-S-methyltransferase genotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases.Semantic proximity Read ↗

Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease PatientsSemantic proximity Read ↗

Deletion of glutathione-s-transferase m1 reduces azathioprine metabolite concentrations in young patients with inflammatory bowel disease.Semantic proximity Read ↗

Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.Semantic proximity Read ↗

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