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Article

Thiopurine effectiveness in patients with Crohn's disease: a study of genetic and clinical predictive factors.

Inflammatory bowel diseases - 1 Jul 2013

Koifman Eduard, Karban Amir, Mazor Yoav, Chermesh Irit, Waterman Matti, Almog Ronit, Ben-Horin Shomron, Eliakim Rami, Krivoy Norberto, Efrati Edna, Chowers Yehuda

Abstract excerpt

BACKGROUND: Thiopurines are efficacious in the treatment of Crohn's disease and were recently shown to induce T-cell apoptosis by modulation of Rac1 activation. To assess whether polymorphisms in Rac1 and other apoptosis-related genes, combined with clinical parameters, can predict response to thiopurines. METHODS: A retrospective cohort of 156 thiopurine-treated patients with Crohn's disease was genotyped for 11...

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PMID: 23669401
DOI: 10.1097/MIB.0b013e31828828d3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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