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Pharmacogenetics of Thiopurines in Inflammatory Bowel Disease

21 Dec 2009

Abstract excerpt

Thiopurines are widely used in the treatment of inflammatory bowel disease (IBD). However, in clinical practice azathioprine (AZA) or 6-mercaptopurine (6-MP) are not effective in one-third of patients and up to one-fifth of patients discontinue thiopurine therapy due to adverse reactions. The observed interindividual differences in therapeutic response and toxicity to thiopurines are explained to a large extent...

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PMID: 20205660
DOI: 10.2174/138161210790112773

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