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Article

Thiopurine Biotransformation and Pharmacological Effects: Contribution of Oxidative Stress.

Current drug metabolism - 1 Jan 2016

Pelin Marco, De Iudicibus Sara, Londero Margherita, Spizzo Riccardo, Dei Rossi Sveva, Martelossi Stefano, Ventura Alessandro, Decorti Giuliana, Stocco Gabriele

Abstract excerpt

BACKGROUND: Thiopurine antimetabolites are important agents for the treatment of severe diseases, such as acute lymphoblastic leukemia and inflammatory bowel disease. Their pharmacological actions depend on biotransformation into active thioguanine-nucleotides; intracellular metabolism is mediated by enzymes of the salvage pathway of nucleotide synthesis and relies on polymorphic enzymes involved in thiopurines'...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26935390
DOI: 10.2174/1389200217666160303104153

Genes

GSTM1
NUDT15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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