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Article

Update on thiopurine pharmacogenetics in inflammatory bowel disease.

Pharmacogenomics - 1 Jul 2015

Roberts Rebecca L, Barclay Murray L

Abstract excerpt

Azathioprine and 6-mercaptopurine remain pivotal therapies for the maintenance of disease remission in patients with Crohn's disease and ulcerative colitis. While thiopurine S-methyltransferase deficiency was the first pharmacogenetic phenomenon to be recognized to influence thiopurine toxicity and reliably predict leukopenia, it does not predict other adverse effects, nor does it explain most cases of thiopurine...

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Source

Identifiers

PMID: 26067482
DOI: 10.2217/pgs.15.29

Genes

NUDT15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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