Article
Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism.
Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2011
Suspène Rodolphe, Aynaud Marie-Ming, Guétard Denise, Henry Michel, Eckhoff Grace, Marchio Agnès, Pineau Pascal, Dejean Anne, Vartanian Jean-Pierre, Wain-Hobson Simon
Abstract excerpt
The human APOBEC3 (A3A-A3H) locus encodes six cytidine deaminases that edit single-stranded DNA, the result being DNA peppered with uridine. Although several cytidine deaminases are clearly restriction factors for retroviruses and hepadnaviruses, it is not known if APOBEC3 enzymes have roles outside of these settings. It is shown here that both human mitochondrial and nuclear DNA are vulnerable to somatic...
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