Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases.

The Journal of general virology - 1 Sept 2005

Mahieux Renaud, Suspène Rodolphe, Delebecque Frédéric, Henry Michel, Schwartz Olivier, Wain-Hobson Simon, Vartanian Jean-Pierre

Abstract excerpt

In the absence of the human immunodeficiency virus type 1 (HIV-1) Vif protein, the host-cell cytidine deaminases APOBEC3F and -3G are co-packaged along with virion RNA. Upon infection of target cells, nascent single-stranded DNA can be edited extensively, invariably giving rise to defective genomes called G-->A hypermutants. Although human T-cell leukemia virus type 1 (HTLV-1) replicates in the same cell type as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APOBEC-3G Deaminase
Share to Cytidine Deaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytosine Deaminase

Share to Genome, Viral

Share to Human T-lymphotropic virus 1

Share to Leukocytes, Mononuclear

Share to Minor Histocompatibility Antigens

Share to RNA Editing

Source

Identifiers

PMID: 16099907
DOI: 10.1099/vir.0.80973-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases.PMID 16099907Read ↗

APOBEC3G targets human T-cell leukemia virus type 1.Semantic proximity Read ↗

Cytidine Deaminases APOBEC3G and APOBEC3F Interact with Human Immunodeficiency Virus Type 1 Integrase and Inhibit Proviral DNA FormationSemantic proximity Read ↗

APOBEC3G & HTLV-1: Inhibition without deaminationSemantic proximity Read ↗

APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G.Semantic proximity Read ↗

APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptaseSemantic proximity Read ↗

Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n.Semantic proximity Read ↗

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism.Semantic proximity Read ↗

Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read ↗

Genetic Editing of Herpes Simplex Virus 1 and Epstein-Barr Herpesvirus Genomes by Human APOBEC3 Cytidine Deaminases in Culture and <i>In Vivo</i>Semantic proximity Read ↗

Human Cytidine Deaminase APOBEC3H Restricts HIV-1 ReplicationSemantic proximity Read ↗

G-->A hypermutation in protease and reverse transcriptase regions of human immunodeficiency virus type 1 residing in resting CD4+ T cells in vivo.Semantic proximity Read ↗

Antiretroviral APOBEC3 Cytidine Deaminases Alter HIV-1 Provirus Integration Site ProfilesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.