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Article

Synthetic circuit identifies subpopulations with sustained memory of DNA damage.

Genes & development - 1 Mar 2011

Burrill Devin R, Silver Pamela A

Abstract excerpt

Differential responses to stimuli can affect how cells succumb to disease. In yeast, DNA damage can create heterogeneous responses. To delineate how a response contributes to a cell's future behavior, we constructed a transcription-based memory circuit that detects DNA repair to isolate subpopulations with heritable damage responses. Strongly responsive cells show multigenerational effects, including growth...

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Identifiers

PMID: 21363961
DOI: 10.1101/gad.1994911
PMCID: PMC3049284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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