Article
Synthetic circuit identifies subpopulations with sustained memory of DNA damage.
Genes & development - 1 Mar 2011
Burrill Devin R, Silver Pamela A
Abstract excerpt
Differential responses to stimuli can affect how cells succumb to disease. In yeast, DNA damage can create heterogeneous responses. To delineate how a response contributes to a cell's future behavior, we constructed a transcription-based memory circuit that detects DNA repair to isolate subpopula...
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