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Article

Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps.

PLoS computational biology - 1 Apr 2013

Zinovyev Andrei, Kuperstein Inna, Barillot Emmanuel, Heyer Wolf-Dietrich

Abstract excerpt

Systematic analysis of synthetic lethality (SL) constitutes a critical tool for systems biology to decipher molecular pathways. The most accepted mechanistic explanation of SL is that the two genes function in parallel, mutually compensatory pathways, known as between-pathway SL. However, recent genome-wide analyses in yeast identified a significant number of within-pathway negative genetic interactions. The...

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PMID: 23592964
DOI: 10.1371/journal.pcbi.1003016
PMCID: PMC3617211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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