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Article

Cellular heterogeneity in DNA alkylation repair increases population genetic plasticity.

Nucleic acids research - 2 Dec 2021

Vincent Maxence S, Uphoff Stephan

Abstract excerpt

DNA repair mechanisms fulfil a dual role, as they are essential for cell survival and genome maintenance. Here, we studied how cells regulate the interplay between DNA repair and mutation. We focused on the adaptive response that increases the resistance of Escherichia coli cells to DNA alkylation damage. Combination of single-molecule imaging and microfluidic-based single-cell microscopy showed that noise in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34850170
DOI: 10.1093/nar/gkab1143
PMCID: PMC8643705

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