Article
IRF7, a functional factor associates with systemic lupus erythematosus.
Cytokine - 1 Jun 2012
Xu Wang-Dong, Zhang Yu-Jing, Xu Ke, Zhai Yu, Li Bao-Zhu, Pan Hai-Feng, Ye Dong-Qing
Abstract excerpt
Systemic lupus erythematosus is an autoimmune disease attributing to a combination of genetic and environmental factors. Abnormal expression/function of type I interferons has been demonstrated with the pathogenesis of SLE, especially IFN-α, which can be regulated by IFN regulatory factor 7 (IRF7). Single nucleotide polymorphisms (SNPs) near/in IRF7 have been substantiated related to onset of SLE, moreover,...
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