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Long noncoding RNAs in B-cell development and activation

6 Jul 2016

Abstract excerpt

Long noncoding RNAs (lncRNAs) are potentially important regulators of cell differentiation and development, but little is known about their roles in B lymphocytes. Using RNA-seq and de novo transcript assembly, we identified 4516 lncRNAs expressed in 11 stages of B-cell development and activation. Most of these lncRNAs have not been previously detected, even in the closely related T-cell lineage. Comparison with...

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PMID: 27381906
DOI: 10.1182/blood-2015-11-680843

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