Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation.

doi:10.1006/smim.1998.0115

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Article

Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation.

Seminars in immunology - 1 Apr 1998

Morrison A M, Nutt S L, Thévenin C, Rolink A, Busslinger M

Abstract excerpt

Pax-5 codes for the transcription factor BSAP which is expressed throughout B cell development except in terminally differentiated plasma cells. Gene targeting experiments in the mouse revealed a differential dependency of fetal and adult B-lymphopoiesis on this transcription factor. BSAP is requ...

Topics

Adult
Animals
B-Lymphocytes
DNA-Binding Proteins
Down-Regulation
Gene Expression Regulation
Gene Expression Regulation, Neoplastic
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukopoiesis

Liver

Lymphoma, Non-Hodgkin

Mice

Mutation

Nuclear Proteins

PAX5 Transcription Factor

Source

Open in PubMed

Identifiers

PMID: 9618759
DOI: 10.1006/smim.1998.0115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9618759-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation.PMID 9618759Read ↗

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