Article
The relationship of glutathione-S-transferases copy number variation and indoor air pollution to symptoms and markers of respiratory disease.
The clinical respiratory journal - 1 Jul 2012
Hersoug Lars-Georg, Brasch-Andersen Charlotte, Husemoen Lise Lotte Nystrup, Sigsgaard Torben, Linneberg Allan
Abstract excerpt
INTRODUCTION: Exposure to particulate matter (PM) may induce inflammation and oxidative stress in the airways. Carriers of null polymorphisms of glutathione S-transferases (GSTs), which detoxify reactive oxygen species, may be particularly susceptible to the effects of PM. OBJECTIVES: To investigate whether deletions of GSTM1 and GSTT1 modify the potential effects of exposure to indoor sources of PM on symptoms...
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