Article
The interaction of glutathione S-transferase M1-null variants with tobacco smoke exposure and the development of childhood asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2009
Rogers A J, Brasch-Andersen C, Ionita-Laza I, Murphy A, Sharma S, Klanderman B J, Raby B A
Abstract excerpt
BACKGROUND: The glutathione S-transferase M1 (GSTM1)-null variant is a common copy number variant associated with adverse pulmonary outcomes, including asthma and airflow obstruction, with evidence of important gene-by-environment interactions with exposures to oxidative stress. OBJECTIVE: To explore the joint interactive effects of GSTM1 copy number and tobacco smoke exposure on the development of asthma and...
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