Copy number variants of GSTM1 and GSTT1 in relation to lung cancer risk in a prospective cohort study.

doi:10.1016/j.annepidem.2009.03.003

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Article

Copy number variants of GSTM1 and GSTT1 in relation to lung cancer risk in a prospective cohort study.

Annals of epidemiology - 1 Aug 2009

Lam Tram Kim, Ruczinski Ingo, Helzlsouer Kathy, Shugart Yin Yao, Li Kelly E, Clipp Sandra, Strickland Paul T, Alberg Anthony J

Abstract excerpt

PURPOSE: Previous studies did not discriminate wild-type from hemizygous genotypes of GSTM1 and GSTT1. In this study, we investigated wild-type, hemizygous deletion, and homozygous deletion genotypes of GSTM1 and GSTT1 and lung cancer risk. METHODS: We conducted a nested case-control study of 143 primary incident lung cancer cases matched to 447 cancer-free controls. Genotyping was carried out using a real-time...

Topics

Adult
Age Factors
Aged
Body Mass Index
Case-Control Studies
Educational Status
Female
Genotype
Glutathione Transferase
Humans
Incidence
Lung Neoplasms
Male
Middle Aged

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Prospective Studies

Risk Factors

Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 19394866
DOI: 10.1016/j.annepidem.2009.03.003
PMCID: PMC2720160

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.