Article
Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.
PLoS pathogens - 10 Feb 2011
Ferrari Guido, Korber Bette, Goonetilleke Nilu, Liu Michael K P, Turnbull Emma L, Salazar-Gonzalez Jesus F, Hawkins Natalie, Self Steve, Watson Sydeaka, Betts Michael R, Gay Cynthia, McGhee Kara, Pellegrino Pierre, Williams Ian, Tomaras Georgia D, Haynes Barton F, Gray Clive M, Borrow Persephone, Roederer Mario, McMichael Andrew J, Weinhold Kent J
Abstract excerpt
In the present study, we analyzed the functional profile of CD8+ T-cell responses directed against autologous transmitted/founder HIV-1 isolates during acute and early infection, and examined whether multifunctionality is required for selection of virus escape mutations. Seven anti-retroviral therapy-naïve subjects were studied in detail between 1 and 87 weeks following onset of symptoms of acute HIV-1 infection....
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