Article
Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells.
Journal of virology - 1 Apr 2008
Daucher Marybeth, Price David A, Brenchley Jason M, Lamoreaux Laurie, Metcalf Julia A, Rehm Catherine, Nies-Kraske Elizabeth, Urban Elizabeth, Yoder Christian, Rock Diane, Gumkowski Julie, Betts Michael R, Dybul Mark R, Douek Daniel C
Abstract excerpt
A clear understanding of the antiviral effects of CD8(+) T cells in the context of chronic human immunodeficiency virus (HIV) infection is critical for the development of prophylactic vaccines and therapeutics designed to support T-cell-mediated immunity. However, defining the potential correlates of effective CD8(+) T-cell immunity has proven difficult; notably, comprehensive analyses have demonstrated that the...
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