Article
Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons.
Development (Cambridge, England) - 1 Jun 2009
Tang Mianzhi, Miyamoto Yasunori, Huang Eric J
Abstract excerpt
Stem cell-based replacement therapy has emerged as a potential strategy to alleviate specific features of movement disorder in Parkinson's disease. However, the current strategy to produce dopamine (DA) neurons from embryonic stem cells has many limitations, including the difficulty of generating DA neurons with high yields. Further insights into the mechanisms that control the neurogenesis of DA neurons will...
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