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Article

The p53-HDM2 gene-gene polymorphism interaction is associated with the development of missed abortion.

Human reproduction (Oxford, England) - 1 May 2011

Fang Yan, Kong Beihua, Yang Qifeng, Ma Daoxin, Qu Xun

Abstract excerpt

BACKGROUND: The interaction between p53 and human double minute 2 (HDM2) plays an important role in apoptosis; therefore, functional polymorphisms in these genes might have adverse effects in early pregnancy. In this study, we investigated whether p53 codon 72 and HDM2 promoter (SNP309) polymorphisms were associated with the development of missed abortion. METHODS: Women with missed abortions (n= 60) and healthy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21339197
DOI: 10.1093/humrep/der017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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