Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2009

Kang Hey-Joo, Feng Zhaohui, Sun Yvonne, Atwal Gurinder, Murphy Maureen E, Rebbeck Timothy R, Rosenwaks Zev, Levine Arnold J, Hu Wenwei

Abstract excerpt

The tumor suppressor protein p53 plays an important role in maternal reproduction in mice through transcriptional regulation of leukemia inhibitory factor (LIF), a cytokine crucial for blastocyst implantation. To determine whether these observations could be extended to humans, a list of single-nucleotide polymorphisms (SNPs) in the p53 pathway that can modify the function of p53 was assembled and used to study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Codon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo Implantation

Share to Fertility

Share to Fertilization in Vitro

Share to Leukemia Inhibitory Factor

Share to Polymorphism, Single Nucleotide

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 19470478
DOI: 10.1073/pnas.0904280106
PMCID: PMC2700980

Genes

LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.PMID 19470478Read ↗

Regulation of female reproduction by p53 and its family members.Semantic proximity Read ↗

p53: A new player in reproductionSemantic proximity Read ↗

p53 signaling pathway polymorphisms associated to recurrent pregnancy loss.Semantic proximity Read ↗

Genetic variants in TP53 and MDM2 associated with male infertility in Chinese populationSemantic proximity Read ↗

Genetic variants in the p53 pathway influence implantation and pregnancy maintenance in IVF treatments using donor oocytes.Semantic proximity Read ↗

Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome.Semantic proximity Read ↗

Differential levels of transcription of p53‐regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosisSemantic proximity Read ↗

TP53 gene Arg72Pro polymorphism and male infertility risk: A meta-analysis.Semantic proximity Read ↗

PKHD1L1 affects fertility in womenSemantic proximity Read ↗

No association of TP53 codon 72 SNP with male infertility: a study in a Chinese population and a meta-analysis.Semantic proximity Read ↗

p53 and risk of endometriosis in Indian women.Semantic proximity Read ↗

Effect of the p53 P72R Polymorphism on Mutant TP53 Allele Selection in Human Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.