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Article

MDM2 SNP309 is associated with endometrial cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2008

Terry Kathryn, McGrath Monica, Lee I-Min, Buring Julie, De Vivo Immaculata

Abstract excerpt

Mouse double-minute 2 homologue (MDM2) is a key negative regulator of p53, a tumor suppressor gene that initiates cell cycle arrest and apoptosis in response to DNA damage and other cellular stresses. A T > G polymorphism found in the promoter region of MDM2 (SNP309) increases MDM2 expression and thereby attenuates p53 activity. We genotyped the MDM2 polymorphism SNP309 in endometrial cancer case-control studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins c-mdm2

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Source

Open in PubMed Open full text

Identifiers

PMID: 18398041
DOI: 10.1158/1055-9965.EPI-07-2872
PMCID: PMC2728574

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MDM2 SNP309 is associated with endometrial cancer risk.PMID 18398041Read ↗

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