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Article

Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans.

The international journal of cardiovascular imaging - 1 Feb 2012

Neumann Serina A, Linder Katherine J, Muldoon Matthew F, Sutton-Tyrrell Kimberly, Kline Christopher, Shrader Catherine J, Lawrence Elizabeth C, Ferrell Robert E, Manuck Stephen B

Abstract excerpt

Atherosclerosis is a heritable trait with little known about specific genetic influences on preclinical measures of plaque formation. Based on relations of parasympathetic-cholinergic function to atherosclerosis and to a choline transporter gene [CHT1 (G/T)] polymorphism, we investigated whether the same allelic variant predicts variation in carotid intima-media thickness (IMT) and plaque formation. Carotid IMT...

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Identifiers

PMID: 21337021
DOI: 10.1007/s10554-011-9831-4
PMCID: PMC3403193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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