Article
Joint associations of 61 genetic variants in the nicotinic acetylcholine receptor genes with subclinical atherosclerosis in American Indians: a gene-family analysis.
Circulation. Cardiovascular genetics - 1 Feb 2013
Yang Jingyun, Zhu Yun, Lee Elisa T, Zhang Ying, Cole Shelley A, Haack Karin, Best Lyle G, Devereux Richard B, Roman Mary J, Howard Barbara V, Zhao Jinying
Abstract excerpt
BACKGROUND: Atherosclerosis is the underlying cause of cardiovascular disease, the leading cause of morbidity and mortality in all American populations, including American Indians. Genetic factors play an important role in the pathogenesis of atherosclerosis. Although a single-nucleotide polymorphism (SNP) may explain only a small portion of variability in disease, the joint effect of multiple variants in a...
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