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Article

Do mutations causing low HDL-C promote increased carotid intima-media thickness?

Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2007

Miller Michael, Rhyne Jeffrey, Hong Seung Ho, Friel Gina, Dolinar Christina, Riley Ward

Abstract excerpt

BACKGROUND: Although observational data support an inverse relationship between high-density lipoprotein (HDL) cholesterol and coronary heart disease (CHD), genetic HDL deficiency states often do not correlate with premature CHD. METHODS: Carotid intima-media thickness (cIMT) measurements were obtained in cases comprising 10 different mutations in LCAT, ABCA1 and APOA1 to further evaluate the relationship between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17113061
DOI: 10.1016/j.cca.2006.10.001
PMCID: PMC1828111

Genes

ABCA1
APOA1
LCAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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