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Article

Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits.

The Journal of pharmacology and experimental therapeutics - 1 Jul 2011

Valle Anne M, Radic Zoran, Rana Brinda K, Mahboubi Vafa, Wessel Jennifer, Shih Pei-an Betty, Rao Fangwen, O'Connor Daniel T, Taylor Palmer

Abstract excerpt

Cholinergic neurotransmission in the central and autonomic nervous systems regulates immediate variations in and longer-term maintenance of cardiovascular function with acetylcholinesterase (AChE) activity that is critical to temporal responsiveness. Butyrylcholinesterase (BChE), largely confined to the liver and plasma, subserves metabolic functions. AChE and BChE are found in hematopoietic cells and plasma,...

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Source

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Identifiers

PMID: 21493754
DOI: 10.1124/jpet.111.180091
PMCID: PMC3126649

Genes

ACHE
BCHE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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