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Article

HFE H63D, C282Y and AGTR1 A1166C polymorphisms and brain white matter lesions in the aging brain.

Journal of neurogenetics - 1 Mar 2011

Gebril Ola H, Kirby Janine, Savva George, Brayne Carol, Ince Paul G

Abstract excerpt

Incidental white matter lesions (WML) are a common neuroradiological finding in elderly people and have been linked to dementia and depression. Various mechanisms including hypoxia and increased production of reactive oxygen species (ROS) are implicated in the etiology of WML. The hemochromatosis (HFE) gene p.H63D and p.C282Y polymorphisms have been linked to dysregulation of iron metabolism and increased levels...

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Source

Identifiers

PMID: 21332426
DOI: 10.3109/01677063.2011.556206

Genes

HFE
AGTR1
APOE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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