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Article

Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Bartzokis George, Lu Po H, Tishler Todd A, Peters Douglas G, Kosenko Anastasia, Barrall Katherine A, Finn J Paul, Villablanca Pablo, Laub Gerhard, Altshuler Lori L, Geschwind Daniel H, Mintz Jim, Neely Elizabeth, Connor James R

Abstract excerpt

Prevalent gene variants involved in iron metabolism [hemochromatosis (HFE) H63D and transferrin C2 (TfC2)] have been associated with higher risk and earlier age at onset of Alzheimer's disease (AD), especially in men. Brain iron increases with age, is higher in men, and is abnormally elevated in several neurodegenerative diseases, including AD and Parkinson's disease, where it has been reported to contribute to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20164577
DOI: 10.3233/JAD-2010-1368
PMCID: PMC3119253

Genes

HFE

Variants

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