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Article

Renin-angiotensin system genetic polymorphisms and brain white matter lesions in older Australians.

American journal of hypertension - 1 Sept 2014

Assareh Amelia A, Mather Karen A, Crawford John D, Wen Wei, Anstey Kaarin J, Easteal Simon, Tan Xiaoyun, Mack Holly A, Kwok John B J, Schofield Peter R, Sachdev Perminder S

Abstract excerpt

BACKGROUND: White matter lesions (WMLs), seen as hyperintensities on T2-weighted magnetic resonance imaging brain scans, are common in the brains of healthy older individuals. They are thought to be related to cerebral small vessel disease and to have a genetic component to their aetiology, and hypertension is thought to be an important risk factor. Genetic polymorphisms in hypertension-related genes may...

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Identifiers

PMID: 24622918
DOI: 10.1093/ajh/hpu035

Genes

AGT
AGTR1
ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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