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Article

Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort.

BMC neurology - 6 Jul 2006

Guerreiro Rita J, Bras Jose M, Santana Isabel, Januario Cristina, Santiago Beatriz, Morgadinho Ana S, Ribeiro Maria H, Hardy John, Singleton Andrew, Oliveira Catarina

Abstract excerpt

BACKGROUND: Pathological brain iron deposition has been implicated as a source of neurotoxic reactive oxygen species in Alzheimer (AD) and Parkinson diseases (PD). Iron metabolism is associated with the gene hemochromatosis (HFE Human genome nomenclature committee ID:4886), and mutations in HFE are a cause of the iron mismetabolism disease, hemochromatosis. Several reports have tested the association of HFE...

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Source

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Identifiers

PMID: 16824219
DOI: 10.1186/1471-2377-6-24
PMCID: PMC1534050

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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