Article
Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2003
Pulliam Joseph F, Jennings C Darrell, Kryscio Richard J, Davis Daron G, Wilson Dianne, Montine Thomas J, Schmitt Frederick A, Markesbery William R
Abstract excerpt
Oxidative stress enhanced by transition metals such as iron forms an attractive hypothesis for neurodegeneration in Alzheimer's Disease (AD). Iron is increased in the brain in AD, but whether this is a primary abnormality or the result of secondary accumulation is unclear. Among several genetic loci associated with AD, the locus at chromosome 6p21 contains the hereditary hemochromatosis gene HFE. To determine...
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