Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heme Oxygenase-1 Gene (GT)n Polymorphism Linked to Deep White Matter Hyperintensities, Not Periventricular Hyperintensities.

Journal of the American Heart Association - 4 Jun 2024

Chen Junting, Li Jinrui, Wang Xiaomian, Fu Xiaoli, Ke Jianxia, Li Jintao, Wen Jia, Cheng Kailin, Li Shuen, Shi Zhu

Abstract excerpt

BACKGROUND: Oxidative stress plays a principal role in the pathogenesis of white matter hyperintensities (WMHs). The induction of heme oxygenase-1 (HO-1) gene in the brain represents 1 of the pivotal mechanisms to counteract the noxious effects of reactive oxygen species, and the transcriptional modulation of HO-1 induction depends on the length of a GT-repeat (GT)n in the promoter region. We investigated whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Heme Oxygenase-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukoencephalopathies

Share to Magnetic Resonance Imaging

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Risk Factors

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 38818928
DOI: 10.1161/JAHA.123.033981
PMCID: PMC11255616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heme Oxygenase-1 Gene (GT)n Polymorphism Linked to Deep White Matter Hyperintensities, Not Periventricular Hyperintensities.PMID 38818928Read ↗

The effect of a promoter polymorphism in the heme oxygenase-1 gene on the risk of ischaemic cerebrovascular events: the influence of other vascular risk factors.Semantic proximity Read ↗

Association of HO-1 (GT)n Promoter Polymorphism and Cardiovascular Disease: A Reanalysis of the Literature.Semantic proximity Read ↗

THE PREVALENCE OF C3953T IL1Β GENE AND G308A TNFΑ GENE POLYMORPHIC VARIANTS IN THE PATIENTS WITH DIFFERENT TYPES OF ENCEPHALOPATHIES.Semantic proximity Read ↗

Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Multiple Sclerosis.Semantic proximity Read ↗

Increased lipid peroxidation and lowered lipid-associated antioxidant defenses mediate the effects of the paraoxonase 1 (PON1) Q192R polymorphism on disabilities and final stroke core volume in mild and moderate strokeSemantic proximity Read ↗

HLA-C*07:01 and HLA-DQB1*02:01 protect against white matter hyperintensities and deterioration of cognitive function: A population-based cohort study.Semantic proximity Read ↗

Heme oxygenase-1 promoter (GT) n polymorphism associates with HIV neurocognitive impairment.Semantic proximity Read ↗

Antioxidant Genetic Profile Modifies Probability of Developing Neurological Sequelae in Long-COVIDSemantic proximity Read ↗

A hemochromatosis allele that protects against Alzheimer's disease injury: A role for H-ferritin.Semantic proximity Read ↗

Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors.Semantic proximity Read ↗

Short (GT) ( n ) repeats in heme oxygenase-1 gene promoter are associated with lower risk of coronary heart disease in subjects with high levels of oxidative stress.Semantic proximity Read ↗

Correlation of geographic distributions of haptoglobin alleles with prevalence of multiple sclerosis (MS) - a narrative literature review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.