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Article

The novel gene twenty-four defines a critical translational step in the Drosophila clock.

Nature - 17 Feb 2011

Lim Chunghun, Lee Jongbin, Choi Changtaek, Kilman Valerie L, Kim Juwon, Park Sung Mi, Jang Sung Key, Allada Ravi, Choe Joonho

Abstract excerpt

Daily oscillations of gene expression underlie circadian behaviours in multicellular organisms. While attention has been focused on transcriptional and post-translational mechanisms, other post-transcriptional modes have been less clearly delineated. Here we report mutants of a novel Drosophila gene twenty-four (tyf) that show weak behavioural rhythms. Weak rhythms are accompanied by marked reductions in the...

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Identifiers

PMID: 21331043
DOI: 10.1038/nature09728
PMCID: PMC3073513

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