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Article

ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila.

Science (New York, N.Y.) - 17 May 2013

Lim Chunghun, Allada Ravi

Abstract excerpt

Evidence for transcriptional feedback in circadian timekeeping is abundant, yet little is known about the mechanisms underlying translational control. We found that ATAXIN-2 (ATX2), an RNA-associated protein involved in neurodegenerative disease, is a translational activator of the rate-limiting clock component PERIOD (PER) in Drosophila. ATX2 specifically interacted with TWENTY-FOUR (TYF), an activator of PER...

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PMID: 23687047
DOI: 10.1126/science.1234785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila.PMID 23687047Read ↗

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