Article
Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Jul 2011
Hara Taichi, Koh Kyunghee, Combs David J, Sehgal Amita
Abstract excerpt
The molecular circadian clock consists of a feedback loop in which canonical clock proteins negatively regulate transcription of their own genes. Timed nuclear entry of these proteins is critical, but regulation of this event is poorly understood. In Drosophila melanogaster, the idea that nuclear entry of PERIOD (PER) is controlled by its partner protein TIMELESS (TIM) has been challenged by several studies. We...
Topics
- Animals
- Animals, Genetically Modified
- Cell Nucleus
- Circadian Rhythm
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation
- Immunoprecipitation
- Luminescent Proteins
- Mutation