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Article

A role for Drosophila ATX2 in activation of PER translation and circadian behavior.

Science (New York, N.Y.) - 17 May 2013

Zhang Yong, Ling Jinli, Yuan Chunyan, Dubruille Raphaëlle, Emery Patrick

Abstract excerpt

A negative transcriptional feedback loop generates circadian rhythms in Drosophila. PERIOD (PER) is a critical state-variable in this mechanism, and its abundance is tightly regulated. We found that the Drosophila homolog of ATAXIN-2 (ATX2)--an RNA-binding protein implicated in human neurodegenerative diseases--was required for circadian locomotor behavior. ATX2 was necessary for PER accumulation in circadian...

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Identifiers

PMID: 23687048
DOI: 10.1126/science.1234746
PMCID: PMC4078874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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