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Article

shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination.

Chromosoma - 1 Jun 2020

Petrillo Cynthia, Barroca Vilma, Ribeiro Jonathan, Lailler Nathalie, Livera Gabriel, Keeney Scott, Martini Emmanuelle, Jain Devanshi

Abstract excerpt

Recombination is crucial for chromosome pairing and segregation during meiosis. SPATA22, along with its direct binding partner and functional collaborator, MEIOB, is essential for the proper repair of double-strand breaks (DSBs) during meiotic recombination. Here, we describe a novel point-mutated allele (shani) of mouse Spata22 that we isolated in a forward genetic screen. shani mutant mice phenocopy...

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Identifiers

PMID: 32388826
DOI: 10.1007/s00412-020-00735-8
PMCID: PMC7546082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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