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Article

HDAC Inhibition in Lupus Models

11 Feb 2011

Abstract excerpt

Systemic lupus erythematosus (SLE) is a prototypic autoimmune inflammatory disease characterized by the production of autoantibodies directed against nuclear antigens such as nucleosomes, DNA and histone proteins found within the body's cells and plasma. Autoantibodies may induce disease by forming immune complexes that lodge in target organs or by crossreacting with targeted antigens and damaging tissue. In...

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PMID: 21327298
DOI: 10.2119/molmed.2011.00055

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